Mycobacteria - specific cytokine responses detect TB infection and distinguish latent from active TB
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چکیده
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تست پوستی توبرکولین: مقاله مروری
Historically, tuberculosis has been the leading cause of death throughout human history. Tuberculosis infection (TB) causes by Mycobacterium tuberculosis that is very dangerous and can affect any parts of the body, especially lungs. Tuberculosis infection still remains a serious threat to human public health due to its contagious nature, capability to stay latent form in host for indefinite tim...
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Accurate biomarkers of Mycobacterium tuberculosis infection activity would significantly improve early diagnosis, treatment and management of M. tuberculosis infection. We hypothesised that circulating B-lymphocytes may be useful biomarkers of tuberculosis (TB) infection status in highly TB-endemic settings. Ex-vivo and in-vitro mycobacteria-specific B-cell ELISPOT assays were used to examine t...
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Immunological diagnosis of tuberculosis (TB) is based on the immune responses against Mycobacterium tuberculosis (MTB). Immunological diagnosis can detect both active and latent TB, and can detect not only pulmonary TB but also extra-pulmonary TB. Compared to conventional diagnosis, immunological diagnostic tests have eminent advantages. On the other hand, there are still some limitations. As i...
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Mycobacterium tuberculosis (Mtb) and filarial coinfection is highly prevalent, and the presence of filarial infections may regulate the Toll-like receptor (TLR)-dependent immune response needed to control Mtb infection. By analyzing the baseline and mycobacterial antigen-stimulated expression of TLR1, 2, 4, and 9 (in individuals with latent tuberculosis [TB] with or without filarial infection),...
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